abstract：:There has been a rapid expansion in the use of IGIV for an ever-growing number of conditions. It is a product with an excellent safety record without the side effects of steroids or other immunosuppressive agents. There have been numerous recent advances in our understanding of the mechanisms of action of IGIV in many...

journal_title：International immunopharmacology

authors： Jolles S,Hughes J

更新日期：2006-04-01 00:00:00

abstract：:The alteration of T helper 1 (TH1) and TH2 responses and related cell-mediated immunity has been supposed to be associated with the immunological pathogenesis in the development of schizophrenia. Increasing evidence suggested the alteration of cytokines in accordance with the antipsychotic treatment as well, so that t...

journal_title：International immunopharmacology

authors： Pae CU,Yoon CH,Kim TS,Kim JJ,Park SH,Lee CU,Lee SJ,Lee C,Paik IH

更新日期：2006-04-01 00:00:00

abstract：:Immunosuppressive drugs are widely used in the therapy of autoimmune disorders to suppress autoreactive T cells. The immune system is regulated by the release of cytokines. Cytokine are potent immunomodulatory molecules that act as mediators of inflammation and the immune response. Primarily secreted by T cell and mac...

journal_title：International immunopharmacology

authors： Pawlik A,Baskiewicz-Masiuk M,Machalinski B,Gawronska-Szklarz B

更新日期：2006-03-01 00:00:00

abstract：:Previously it was shown that treatment with mycophenolate mofetil (MMF) attenuated renal inflammation and glomerular injury in a model of diabetes. However, the mechanism involved in the renoprotective effects of MMF in experimental diabetes has not been clearly delineated. Diabetes was induced by injection of strepto...

journal_title：International immunopharmacology

authors： Wu YG,Lin H,Qi XM,Wu GZ,Qian H,Zhao M,Shen JJ,Lin ST

更新日期：2006-03-01 00:00:00

abstract：:Thermal injury may lead to systemic inflammatory response, and multiple organ failure. Generation of reactive oxygen radicals and lipid peroxidation play important roles in burn-induced remote organ injury. In the present study, we investigated the putative protective effect of local or systemic beta-glucan treatment ...

journal_title：International immunopharmacology

authors： Toklu HZ,Sener G,Jahovic N,Uslu B,Arbak S,Yeğen BC

更新日期：2006-02-01 00:00:00

abstract：:Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

journal_title：International immunopharmacology

authors： Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

更新日期：2006-02-01 00:00:00

abstract：:Nicotine, the major addictive component of tobacco, is an immunomodulator that impacts on many cells, including immune cells involved in inflammatory processes. Nicotine also induces oxidative damage to the vascular endothelium and accentuates lipid peroxidation, resulting in vascular cell dysfunction. Furthermore, va...

journal_title：International immunopharmacology

authors： Patton GW,Powell DA,Hakki A,Friedman H,Pross S

更新日期：2006-01-01 00:00:00

abstract：:In the present study, we demonstrated hepatic NK cells in murine chronic HBsAg carriers for the first time. It was found that the number of hepatic NK cells was decreased; natural activation of hepatic NK cells was declined; and cytotoxicity of hepatic NK cells was attenuated, which might relate to the down-regulated ...

journal_title：International immunopharmacology

authors： Chen Y,Wei H,Sun R,Tian Z

更新日期：2005-12-01 00:00:00

abstract：:Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS). After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact ...

journal_title：International immunopharmacology

authors： Zhang Y,Liu J,Jia W,Zhao A,Li T

更新日期：2005-12-01 00:00:00

abstract：:Endometriosis is a gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. Moreover, immunological abnormalities of cell-mediated and humoral immunity may be associated with the pathogenesis of endometriosis. The effects of peritoneal fluid (PF) from endometriosis patients on the expre...

journal_title：International immunopharmacology

authors： Lee KS,Baek DW,Kim KH,Shin BS,Lee DH,Kim JW,Hong YS,Bae YS,Kwak JY

更新日期：2005-11-01 00:00:00

abstract：:Isoflavones, which are phytoestrogens present in large quantities in soy and soy-derived products, have estrogenic activity, inhibit protein tyrosine kinase, and exert other effects in the human body. Thus, the recent spread of soy consumption in Western populations emphasizes the need to more fully understand the pot...

journal_title：International immunopharmacology

authors： Zhao JH,Sun SJ,Horiguchi H,Arao Y,Kanamori N,Kikuchi A,Oguma E,Kayama F

更新日期：2005-10-01 00:00:00

abstract：:The polysaccharide PSPP (purified sweet potato polysaccharide), isolated and purified from the roots of Ipomoea batatas, was found to be a glucan with a molecular weight of 53.2 kDa and specific rotation of +115.0 degrees (ca. 0.80, H(2)O). On the basis of methylation analysis, periodate oxidation, Smith degradation, ...

journal_title：International immunopharmacology

authors： Zhao G,Kan J,Li Z,Chen Z

更新日期：2005-08-01 00:00:00

abstract：:In the present study, antigenic cross-reactivity of OMPs was investigated in several species of bacterial pathogens. Heterogeneous mouse or fish antisera were used to ascertain OMPs with cross-reactivity and cluster analysis was performed to analyze the distribution of cross-antigenic OMPs in diverse bacterial strains...

journal_title：International immunopharmacology

authors： Xu C,Wang S,Zhaoxia Z,Peng X

更新日期：2005-07-01 00:00:00

abstract：:Endothelial cells play an important role in inflammatory diseases like rheumatoid arthritis by recruitment of inflammatory cells. The cytokines TNF-alpha and IL-1beta are major inducers of endothelial cell activation and are stimulators of inflammatory signal transduction pathway involving p38 MAPK (mitogen-activated ...

journal_title：International immunopharmacology

authors： Westra J,Kułdo JM,van Rijswijk MH,Molema G,Limburg PC

更新日期：2005-07-01 00:00:00

abstract：:In search of a potent immunomodulator to be used as an immunoprophylactic agent and as adjunct to chemotherapy against Leishmania infection, two analogs of muramyl dipeptide, viz. N.Ac-norMur-MeVal-D-isoGln (86/448) and N.AcMur-Acc-D-isoGln (89/729) were evaluated for desired activity. Effect of these peptides on cell...

journal_title：International immunopharmacology

authors： Puri A,Sahai R,Haq W,Zaidi A,Guru PY,Tripathi LM,Srivastava VM

更新日期：2005-06-01 00:00:00

abstract：:The Ginkgo biloba extract, EGb 761, contains flavonoid glycosides and unique terpene lactones as major active components. In this study, we determined the anti-inflammatory effect of the water-soluble portion (GH415) of the EGb 761 on the inflammation caused by Candida albicans, a major ethiological agent that causes ...

journal_title：International immunopharmacology

authors： Han Y

更新日期：2005-06-01 00:00:00

abstract：:Compared with freshly isolated peripheral blood natural killer (NK) cells, the YT and NK-92 cell lines are characterized by elevated cytolytic activity. The molecular mechanisms underlying the rapid proliferation and enhanced lytic activity of NK cell lines are poorly understood. Investigation of these cell lines reve...

journal_title：International immunopharmacology

authors： Liang S,Zhang J,Wei H,Sun R,Tian Z

更新日期：2005-05-01 00:00:00

abstract：:Amaranthus spinosus Linn. (thorny amaranth), a plant that grows in the wild fields of Taiwan, is extensively used in Chinese traditional medicine to treat diabetes. There have been no published studies on the immunological effects of A. spinosus. To determine whether A. spinosus has immuno-modulatory effects and clari...

journal_title：International immunopharmacology

authors： Lin BF,Chiang BL,Lin JY

更新日期：2005-04-01 00:00:00

abstract：:Plant extracts have been widely evaluated for possible immunomodulatory properties. We have earlier reported that ethanolic extract of Boerhaavia diffusa root, a plant used in Indian traditional medicine, has significant immunomodulatory potential. B. diffusa hexane, chloroform and ethanol extracts, and two pure compo...

journal_title：International immunopharmacology

authors： Pandey R,Maurya R,Singh G,Sathiamoorthy B,Naik S

更新日期：2005-03-01 00:00:00

abstract：:Glucocorticoids (GC) are frequently used for therapy of various inflammatory lung diseases by either systemic or inhalative application. Because the oral application often has various side effects and because the inhalative application is not as potent, new formulations of GCs are required. We evaluated the effect of ...

journal_title：International immunopharmacology

authors： Frankenberger M,Häussinger K,Ziegler-Heitbrock L

更新日期：2005-02-01 00:00:00

abstract：:To survey the immune regulatory function of recombinant human prolactin (rhPRL) and its potential application in adoptive immunotherapy, CB17-SCID mice were loaded with human colon adenocarcinoma HT-29 cells (5 x 10(5) cells/mouse, i.p.) 24 h before adoptive transfer with the purified human NK cells followed by rhPRL ...

journal_title：International immunopharmacology

authors： Zhang J,Sun R,Wei H,Tian Z

更新日期：2005-02-01 00:00:00

abstract：:Despite the use of increasingly specific immunosuppressive therapy, rejection remains the leading cause of death in cardiac transplant patients. Endomyocardial biopsy (EMB) is the gold standard for early detection and monitoring of cardiac transplant rejection. However, this approach is invasive and not suitable for r...

journal_title：International immunopharmacology

authors： Zupan I,Vrtovec B,Breskvar UD,Gabrijelcic T

更新日期：2005-01-01 00:00:00

abstract：:The early safety and efficacy of tacrolimus after liver transplantation has been shown in two multicenter trials. Herein, we report our single-center long-term follow-up of a randomized controlled trial. As part of a European multicenter trial, 121 patients entered the study at our institution and were randomly assign...

journal_title：International immunopharmacology

authors： Jonas S,Neuhaus R,Junge G,Klupp J,Theruvat T,Langrehr JM,Settmacher U,Neuhaus P

更新日期：2005-01-01 00:00:00

abstract：:Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, ...

journal_title：International immunopharmacology

authors： Bi XL,Yang JY,Dong YX,Wang JM,Cui YH,Ikeshima T,Zhao YQ,Wu CF

更新日期：2005-01-01 00:00:00

abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

journal_title：International immunopharmacology

authors： ElSohly MA,Gul W,Murphy TP

更新日期：2004-12-20 00:00:00

abstract：:TNF-alpha converting enzyme (TACE) is a validated therapeutic target for the development of oral tumor necrosis factor-alpha (TNF-alpha) inhibitors. Here we report the pre-clinical results and characterization of a selective and potent TACE inhibitor, (2R, 3S)-2-([[4-(2-butynyloxy)phenyl]sulfonyl]amino)-N,3-dihydroxyb...

journal_title：International immunopharmacology

authors： Zhang Y,Hegen M,Xu J,Keith JC Jr,Jin G,Du X,Cummons T,Sheppard BJ,Sun L,Zhu Y,Rao VR,Wang Q,Xu W,Cowling R,Nickerson-Nutter CL,Gibbons J,Skotnicki J,Lin LL,Levin J

更新日期：2004-12-20 00:00:00

abstract：:The antiangiogenic activity of Tinospora cordifolia was studied using in vivo as well as in vitro models. In vivo antiangiogenic activity was studied using B16F10 melanoma cell-induced capillary formation in animals. Intraperitoneal administration of the extract at a concentration of 20 mg/kg significantly inhibited t...

journal_title：International immunopharmacology

authors： Leyon PV,Kuttan G

更新日期：2004-12-15 00:00:00

abstract：:Treatment of asthma with corticosteroids results in downregulation of eosinophilic airway inflammation. We evaluated in vitro the activity of an "inhaled" corticosteroid, mometasone furoate (MF), and of a "systemic" corticosteroid, dexamethasone (DEX), on eosinophil functions, i.e. adhesion molecule expression and cel...

journal_title：International immunopharmacology

authors： Sale R,Sabatini F,Silvestri M,Serpero L,Petecchia L,Rossi GA

更新日期：2004-12-15 00:00:00

abstract：:Autoimmune, lupus-prone MRL lpr/lpr mice were treated orally with oxo-quinoline-3-carboxamide (ABR-25757), a newly developed immunomodulator. Treatment was initiated in one set of experiment at the age of 10 weeks, before the onset of clinically apparent disease, and in another set at 15 weeks, after the development o...

journal_title：International immunopharmacology

authors： Carlsten H,Jonsson C,Bokarewa M,Svensson L,Tarkowski A

更新日期：2004-11-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus is a well-known teratogen, which might cause growth retardation, malformations and fetal death. We have previously shown, that potentiation of the maternal immune system (immunopotentiation) might protect the embryo from diabetes teratogenicity. Therefore, in the present study we fu...

journal_title：International immunopharmacology

authors： Savion S,Gidon-Dabush S,Fein A,Torchinsky A,Toder V

更新日期：2004-10-01 00:00:00

abstract：:We studied the effect of Brazilian propolis on scratching behavior induced by compound 48/80 and histamine in ICR mice. Propolis granular A.P.C dose-related inhibited scratching behavior induced by compound 48/80 and significant inhibition were observed at 1000 mg/kg. However, histamine-induced scratching behavior was...

journal_title：International immunopharmacology

authors： Shinmei Y,Hossen MA,Okihara K,Sugimoto H,Yamada H,Kamei C

更新日期：2004-10-01 00:00:00

abstract：:Production of IgG in response to virus infection is central to antiviral immune effector functions and a hallmark of B cell memory. Antiviral antibodies (Abs) recognising viral glycoproteins or protein antigen displayed on the surface of virions or virus-infected cells are crucial in rendering the virus noninfectious ...

journal_title：International immunopharmacology

authors： Budt M,Reinhard H,Bigl A,Hengel H

更新日期：2004-09-01 00:00:00

abstract：:Since leukocyte adhesion to endothelial cells is crucial for extravasation of leukocytes to sites of inflammation, inhibition of cell-cell adhesion has been suggested as a means to achieve selective modulation of the immune system. We have, using a static in vitro adhesion assay involving adhesion of granulocytes to t...

journal_title：International immunopharmacology

authors： Uppugunduri S,Gautam C

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:We examined the effects of the immunosuppressive neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) on rat endotoxin-induced uveitis, and to measure the expression of inflammatory cytokines and chemokines with and without the alpha-MSH treatment over the course of the disease. METHODS:We injected Le...

journal_title：International immunopharmacology

authors： Nishida T,Miyata S,Itoh Y,Mizuki N,Ohgami K,Shiratori K,Ilieva IB,Ohno S,Taylor AW

更新日期：2004-08-01 00:00:00

abstract：:Phospholipase C (PLC)gamma and phospholipase D (PLD) play pivotal roles in the signal transduction required for various cellular responses, including cell proliferation and differentiation. Dendritic cells (DCs), which are professional antigen-presenting cells, can be generated from human monocytes by stimulating the ...

journal_title：International immunopharmacology

authors： Kang HK,Lee HY,Lee YN,Jo EJ,Kim JI,Kim GY,Park YM,Min DS,Yano A,Kwak JY,Bae YS

更新日期：2004-07-01 00:00:00

abstract：:We attempted the phenotypic characterization of peripheral blood (PB) cells after daily administration of macrophage colony-stimulating factor (M-CSF) in mice. The number of CD11b+ cells was increased by M-CSF treatment (2- and 5-day injections). Notably, CD11bbrightCD11cdim, CD11b+CD11c+ and CD11b+CD80+ cells were si...

journal_title：International immunopharmacology

authors： Misawa E,Sakurai T,Yamada M,Tamura Y,Motoyoshi K

更新日期：2004-06-01 00:00:00

abstract：:The melanoma differentiation associated gene-7 (mda-7) cDNA was isolated by virtue of being induced during melanoma differentiation. Initial gene transfer studies convincingly demonstrated potent antitumor effects of mda-7. Further studies showed that the mechanism of antitumor activity was due to induction of apoptos...

journal_title：International immunopharmacology

authors： Chada S,Sutton RB,Ekmekcioglu S,Ellerhorst J,Mumm JB,Leitner WW,Yang HY,Sahin AA,Hunt KK,Fuson KL,Poìndexter N,Roth JA,Ramesh R,Grimm EA,Mhashilkar AM

更新日期：2004-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS [endotoxin]), a structural component of gram-negative bacteria, is implicated in the pathogenesis of septic shock. Lipid A is an evolutionarily conserved region of LPS that has been identified as the toxic component of LPS. Therapeutic strategies for the treatment of septic shock in humans are ...

journal_title：International immunopharmacology

authors： Jiang Z,Hong Z,Guo W,Xiaoyun G,Gengfa L,Yongning L,Guangxia X

更新日期：2004-04-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE), an the active component of propolis, is known to have anticarcinogenic, antiviral and various biological activities; however, the effect of CAPE on the immunomodulatory activity in vivo remains unknown. We have investigated the effect of CAPE on the immune system in female Balb/c m...

journal_title：International immunopharmacology

authors： Park JH,Lee JK,Kim HS,Chung ST,Eom JH,Kim KA,Chung SJ,Paik SY,Oh HY

更新日期：2004-03-01 00:00:00

abstract：:A body of evidence indicates that the therapeutic activity of antidepressants is connected with their modulatory effect on the inflammatory response system and cell-mediated immunity. The present study was carried out to examine the effects of antidepressant agents, such as imipramne, venlafaxine, l-5-hydroxytryptopha...

journal_title：International immunopharmacology

authors： Kubera M,Kenis G,Bosmans E,Kajta M,Basta-Kaim A,Scharpe S,Budziszewska B,Maes M

更新日期：2004-02-01 00:00:00